ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .
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The following Gram negative, Gram positive bacteria, clinical isolates, and fungi were antimicrobual for the experiment: Table 2 Minimum inhibitory concentration of Vasicine acetate against tested bacteria and fungi. Shade dried and coarsely powdered leaves of A. The physical and spectroscopic data were compared with those reported in the literature [ 15 ].
Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper
HPLC chromatograms of the ethanol extract of the leaves of Adhatoda vasica. Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals. Medicinal plants are important sources of practical drugs for people throughout the year.
The free radical scavenging activity was calculated as follows:. Antifeedant and toxic activity of Adhatoda vasica leaf extract against Spodoptera littoralis Lep. Introduction Natural products still remain the most important source lf discovery of new and potential drug molecules.
Accumulation of vasicine and vasicinone in tissue cultures of Adhatoda aactivity and evaluation of the free radical-scavenging activities of the various crude extracts. Council of Scientific and Industrial Research; Journal of Natural Products. Vasicine acetate showed moderate antibacterial activity compared to Vasicine.
BoxRiyadhSaudi Arabia. Acanthaceae is used in the indigenous system of medicine in India. Cytotoxic studies against A lung adenocarcinoma cancer cell aantimicrobial showed Vasicine acetate to be the most potent compound Table 4. Streptomycin was used as positive control for bacteria and Ketoconazole as positive control for fungi. Clinical and Laboratory Standards Institute; Ray of hope for cancer patients.
Antibacterial Activity of Leaf Extracts of Adhatoda vasica – MAHE Digital Repository
The plant is reported to show abortifacient [ 7 ], antimicrobial [ 89 ], and antitussive activities [ 10 ]. The crude extract of A. Classical Uses of Medicinal Plants. Essential oils of the leaves of A. Minimum Inhibitory Concentration MIC Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ].
Minimum inhibitory concentration of Vasicine acetate against tested bacteria and fungi. The chemicals are given in delta scale with TMS as an internal standard.
BHT is used as standard of antioxidant. The structure of the isolated compound Vasicine and Vasicine acetate Figure 1.
Negative control was prepared using respective solvents. All melting point values are uncorrected and taken by open capillary method on a heating block Instrument.
Journal of Natural Product and Plant Resources. The emergence of drug-resistant pathogens and the increase in diseases affecting the immune system have greatly intensified the need to investigate new bioactive metabolites for potential pharmaceutical and industrial applications [ 1 antimicrobual, 2 ].
The worldwide threat of antimicrobial resistance. The alkaloid Vasicine was isolated from ethanolic extract of the leaves of A.