Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.

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This allows the initial geomtarix release to be minimized and therefore the drug geomahrix can be controlled at a near constant level while the barrier layers undergo erosion or swelling [ 5 ]. Adequate controlled plasma drug levels, reduced side effects as well as improved patient compliance are some of the benefits that these systems may offer. More uniform delivery of drug into the systemic circulation can be achieved because bimodal release systems increase the rate of drug release when the ability of the body to absorb the drug decreases.

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

The technology proved to have potential benefits in terms of providing flexible drug release by increasing the amount of modules in an arrangement. It was concluded that the donut-shaped PEO tablets with an aperture were capable of providing zero-order drug release as the effect of surface area on release kinetics is reduced. Results showed that the mini-tablets with HPMC showed the most potential for achieving zero-order drug release.

It has been shown that the combination of these two drugs results in an important reduction of low density lipoprotein cholesterol as well as desirable variations in high density lipoprotein cholesterol [ 83 ]. Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. The technology essentially leads a pursatile drug release where the drug is released in pulses that are separated by defined time intervals.

Zero-order drug delivery system: A tchnology that was conducted by Fassihi and co-workers investigated zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system.

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Transport mechanisms and device design. Polymeric materials play an important role in the functioning of these systems. Dissolution studies over 16 hours showed that the entire amount of drug was released in a zero-order manner with no initial burst release [ gdomatrix ]. Principally, it is a new clinically oral drug delivery technology which allows, with a high degree of precision, the timed delivery of drugs that employs a press-coating technique.


HPMC is one of the most common release modifiers in matrix tablets. A study done by Efentakis and co-workers investigated the effect of polymeric substances on drug release.

This review thus discusses the application of altered geometric technology and its role in controlled oral drug delivery, focusing primarily on the types of polymers that have been employed in developing geometrically modified systems, the interplay of system geometry and polymeric selection ultimately contributing to the type of drug release patterns that are attained.

Correlation between drug dissolution and polymer hydration: Swelling and release mechanism study. These geometric manipulations may also be employed to develop drug delivery systems for the treatment of geomtarix biological conditions where zero-order drug release is not optimal, for example chronotherapy for heart conditions [ 46 ] or the scheduled treatment of asthma and inflammation [ 47 ].

Article | Geomatrix Technology: A Short Review | Inventi Journals

Multilayered hydrophilic matrices as constant release devices. Namdeo expressed that multilayered tablets have demonstrated promise, possessing various benefits, namely the ability to prevent interactions between drugs and excipients; and by providing an array of release profiles in one delivery system of either the same or different drugs, treatment for conditions that require a regimen of more than one drug, immediate drug release using a disintegrating monolithic matrix in order to achieve an initial peak in plasma drug level, delayed drug release using an eroding monolithic matrix which may deliver another active drug to a different part of the gastrointestinal tract, providing controlled drug release instituting a swellable monolithic matrix and better control and regulation of release profiles by retarding initial burst release and achieving zero-order kinetics [ 64 ].

When the solvent penetrates the core layer, the core swells and dissolves, this causes the coating shell to break thereby rapidly releasing the drug [ 4 ]. He developed a specific punch that is able to change the depth of the cup tablet, thus allowing it to carry various cores in terms of hardness and mass. Studies of hydroxypropylmethylcellulose donut-shaped tablets. This system showed fine potential for providing enhanced bioavailability and targeted delivery to the small intestine.

The tablets were prepared by layering three powders and compressing them with a punch.

Results showed that the tablet was capable of delivering the drug constantly over 24 hours and was not dependent on the agitation or release medium [ 93 etchnology. Design and evaluation of transdermal drug delivery of ketotifen fumarate.


Our technical experts are well positioned to bring such expertise to realize the business benefits. The study focused on a core tablet that contained venlafaxine HCl and Methocel KM as the drug carrier. The efficiency of cup tablets with varying depths and the optimal formulation in terms of drug release were investigated in the study. The core layer contained theophylline while the outer layers were composed of polymers and excipients in order to delay the interaction of the core layer with water, thereby delaying and controlling the drug release.

A novel compression-coated doughnut-shaped tablet design for zero-order sustained release. The system consisted of a disc-shaped matrix core that was compression-coated on one surface as well as at the circumference in order to form a cup around the core.

According to geometry of core, zero-order kinetics. Various arrangements of modules to form different structures. It has been shown that both immediate and sustained drug delivery can be obtained through a single triple-layered tablet [ 4 ].

SkypePharma [ 85 ]. A bilayered tablet for the delivery of propranolol hydrochloride was developed by Patra and co-workers. The device was ttechnology coated with a poly vinylpyrrolidone – vinyl acetate copolymer that partially or completely surrounded the semipermeable membrane and covered the passageway in the same manner as a plug.

Hydrophilic and hydrophobic polymers were employed and evaluated as the coating layers. These tablets did not adhere to either biological tissues or solids, thus proving to be more effective than the uncoated systems [ 45 ]. Network Engineering and Administration. The tablets employing this technology can be easily manufactured using technokogy production equipment.

Technologu coating is a good technique for producing this type of time-dependent release. This leaves the sides of the core layer exposed. Table 2 Summary of the geonatrix of polymers influencing the behavior and release characteristics of multilayered tablets.

Various Drug Release Profiles Achievable by Triple-Layered Tablets It has been shown that both immediate and sustained drug delivery can be obtained through a single triple-layered tablet [ 4 ]. Zero-order release from biphasic polymer hydrogels.